Protective Effects of Ginsenoside Rd on PC12 Cells against Hydrogen Peroxide(Pharmacology)
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概要
- 論文の詳細を見る
Oxidative stress-induced cell damage has been implicated in a variety of neurodegenerative disorders. In the current study, we investigated the protective role of ginsenoside Rd against the cytotoxicity induced by exposure to hydrogen peroxide (H_2O_2) and the underlying mechanism in the PC12 cell line. The protective effects of ginsenoside Rd (1,10μM) on H_2O_2-induced cytotoxicity may be ascribed to its antioxidative properties by reducing the intracellular reactive oxygen species level; decreasing malondialdehyde production, a common index of lipid peroxidation; and enhancing the antioxidant enzymatic activities of superoxide dismutase and glutathione peroxidase. Additionally, ginsenoside Rd could stabilize the mitochondrial membrane potential after H_2O_2 exposure. These findings suggested that ginsenoside Rd may be considered a potential antioxidant agent and should encourage further research in neurodegenerative diseases to explore the potential neuroprotective effects of ginsenoside Rd.
- 公益社団法人日本薬学会の論文
- 2008-10-01
著者
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Zhao Gang
Department Of Cardiovascular Medicine Graduate School Of Medicine Sciences Kyushu University
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Cao Rong
Pla Institute Of Neurosciences Fourth Military Medical University
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YE Ruidong
Department of Neurology, Xijing Hospital, Fourth Military Medical University
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HAN Junliang
Department of Neurology, Xijing Hospital, Fourth Military Medical University
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KONG Xiangwei
College of Stomatology, Fourth Military Medical University
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ZHAO Lingzhou
College of Stomatology, Fourth Military Medical University
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RAO Zhiren
PLA Institute of Neurosciences, Fourth Military Medical University
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Han Junliang
Department Of Neurology Xijing Hospital Fourth Military Medical University
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Kong Xiangwei
College Of Stomatology Fourth Military Medical University
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Rao Zhiren
Pla Institute Of Neurosciences Fourth Military Medical University
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Ye Ruidong
Department Of Neurology Xijing Hospital Fourth Military Medical University
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Zhao Lingzhou
College Of Stomatology Fourth Military Medical University
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Zhao Gang
Department Of Neurology Xijing Hospital Fourth Military Medical University
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