Synthesis, Anti-bacterial and Anti-oxidant Properties of Thiadiazaphosphol-2-ones

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概要

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• 4-Amino-5-phenyl-4H-1,2,4-triazole-3-thiol (1) underwent facile condensation with various phosphorus dichlorides (2a-j) in the presence of triethylamine in dry tetrahydrofuran at 60-65℃ and afforded corresponding thiadiazaphosphol-2-ones (3a-j). Their chemical structures were characterized using IR, ^1H-, ^<13>C-, ^<31>PNMR and Mass spectral studies. All the title compounds were screened for antioxidant properties by radical scavenging methods such as 1,1-diphenyl-2-picryl hydrazyl (DPPH), hydroxyl and lipid peroxidation. They exhibited potent in vitro antioxidant activity dose dependently. Their bioassay showed them to possess significant antibacterial activity.

• 公益社団法人日本薬学会の論文
• 2008-10-01

著者

• Veera Narayana

  Department of Chemistry, Sri Venkateswara University

• Balakrishna Avula

  Department of Chemistry, Sri Venkateswara University

• Suresh Reddy

  Department of Chemistry, Sri Venkateswara University

• Suresh Reddy

  Department Of Chemistry Biochemistry S.v. University

• Veera Narayana

  Department Of Chemistry Biochemistry S.v. University

• Balakrishna Avula

  Department Of Chemistry Biochemistry S.v. University

• Kumar Nayak

  Bio-organic Division Barc

• MANJUNATH Manubolu

  Department of Chemistry, Biochemistry, S.V. University

• DEVENDRANATH REDDY

  Department of Chemistry, Biochemistry, S.V. University

• Devendranath Reddy

  Department Of Chemistry Biochemistry S.v. University

• Manjunath Manubolu

  Department Of Chemistry Biochemistry S.v. University

• Balakrishna Avala

  Department of Chemistry, Biochemistry, S.V. University

関連論文

• One-Step Synthesis and Bioassay of N-Phosphoramidophosphonates
• Synthesis, Anti-bacterial and Anti-oxidant Properties of Thiadiazaphosphol-2-ones
• Synthesis and Antimicrobial Activity of Novel Phosphorus Heterocycles with Exocyclic P-C Link
• Synthesis and Antimicrobial Activity of N-(Substituted)-N'-(2,3-dihydro-2-oxido-5-benzoyl-1H-1,3,2-benzodiazaphosphol-2-yl) Ureas

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