Spermine Moiety Attached to the C-5 Position of Deoxyuridine Enhances the Duplex Stability of the Phosphorothioate DNA/Complementary DNA and Shows the Susceptibility of the Substrate to RNase H
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概要
- 論文の詳細を見る
Novel phosphorothioate-modified oligodeoxynucleotides (S-ODNs) containing a deoxyuridine derivative bearing a spermine moiety at the C-5 position were synthesized. The study of the thermal stability and the thermodynamic stability showed that the modified S-ODNs have been able to form the stable duplexes with the complementary DNA. It was also found that the duplex composed of the modified S-ODN and its complementary RNA strand is the substrate for Escherichia coli RNase H, and the cleavage of the RNA strand by the enzyme was almost similar as in the case of the unmodified one.
- 2008-09-01
著者
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MORIGUCHI Tomohisa
Graduate School of Engineering, Gunma University
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SAKAI Hideaki
Graduate School of Engineering, Gunma University
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SUZUKI Hideo
Graduate School of Engineering, Gunma University
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SHINOZUKA Kazuo
Graduate School of Engineering, Gunma University
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Shinozuka Kazuo
Graduate School Of Engineering Gunma University
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Moriguchi Tomohisa
Graduate School Of Engineering Gunma University
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Sakai Hideaki
Graduate School Of Engineering Gunma University
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Suzuki Hideo
Graduate School Of Engineering Gunma University
関連論文
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