小児用シロップ剤の粘度と計量器への付着損失との定量的関係

概要

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We determined the adhesion loss in a metering glass for 9 types of syrup for infants, and investigated the relationship between the adhesion loss and the rheological properties of the syrups. There was a good correlation (r^2=0.981) between the viscosity of the syrups and percentage syrup residues on the metering glass. Further, from the viewpoints of accuracy and efficiency in dispensing, our finding that percentage residues for a dispenser were much lower (<0.15%) than for the metering glass suggested that it was better to use a dispenser for dispensing viscous syrups with a viscosity of at least 50-60 mPa・s. The results of our examination of syrup viscosities in the present study are expected to be useful information for their administration, and to contribute to the establishment of dispensing procedures based on scientific evidence.
日本医療薬学会の論文
2008-07-10