Immunohistochemical Analysis of Benign Mixed and Mesenchymal Odontogenic Tumors
スポンサーリンク
概要
- 論文の詳細を見る
Benign mixed and mesenchymal odontogenic tumors (ameloblastic fibroma, ameloblastic fibrodentinoma, ameloblastic fibro-odontomas, odontogenic fibroma and odontogenic myxoma) were immunohistochemically examined using antibodies against amelogenin, cytokeratin 19, bcl-2, hepatocyte growth factor (HGF), c-Met, transforming growth factor-β (TGF-β), TGF-β receptors and Ki-67 to know cytodifferentiation, epithelial-mesenchymal interaction and proliferative activity. Expression of amelogenin was detected in odontogenic epithelial cells and enamel matrices in ameloblastic fibro-odontomas, and cytokeratin 19 was expressed in odontogenic epithelial cells, indicating odontogenic epithelial properties. Expressions of bcl-2, HGF, TGF-β, TβR I and TβR II were detected in odontogenic epithelial and mesenchymal cells in mixed and mesenchymal odontogenic tumors, while expression of c-Met was detected in odontogenic epithelial cells. Odontogenic epithelial and mesenchymal cells sporadically showed positive reactions for Ki-67 in mixed and mesenchymal odontogenic tumors, and no apparent differences were obtained among these tumors or between the components. Conclusion: Immunohistochemical localization of HGF, TGF-β and their receptors suggests that these growth factor signaling are effective in the epithelial component in paracrine and autocrine manner in mixed and mesenchymal odontogenic tumors. These results of growth factor signaling suggest that certain epithelial-mesenchymal interactions are related to neoplastic cell growth in these tumors.
- 特定非営利活動法人日本臨床口腔病理学会の論文
- 2003-12-25
著者
-
Ooya K
Tohoku Univ. Graduate School Of Dentistry Sendai Jpn
-
Ooya Kiyoshi
Division Of Oral Pathology Department Of Oral Medicine And Bioregulation Tohoku University Graduate
-
Kumamoto Hiroyuki
Division of Oral Pathology, Department of Oral Medicine and Bioregulation, Tohoku University Graduat
-
Yoshida Mitsuhide
Divisions of Oral Pathology, Department of Oral Medicine and Bioregulation, and Pediatric Dentistry,
-
Ooya Kiyoshi
Division Of Oral Pathology Department Of Oral Medicine And Surgery Tohoku University Graduate School
-
Onodera Ken
東北大学 歯研究 口腔病態生体防御
-
Kumamoto Hiroyuki
Division Of Oral Pathology Department Of Oral Medicine And Bioregulation Tohoku University Graduate
-
Kumamoto H
Division Of Oral Pathology Department Of Oral Medicine And Bioregulation Tohoku University Graduate
-
MAYANAGI Hideaki
Division of Pediatric Dentistry, Tohoku University Graduate School of Dentistry
-
Yoshida Mitsuhide
Division Of Pediatric Dentistry Department Of Oral Health And Development Sciences Tohoku University
-
Mayanagi H
Division Of Pediatric Dentistry Department Of Lifelong Oral Health Sciences Tohoku University Gradua
-
Mayanagi Hideaki
Division Of Pediatric Dentistry Department Of Oral Health And Development Sciences Tohoku University
-
Mayanagi Hideaki
Division Of Pediatric Dentistry Department Of Oral Health And Development Sciences Tohoku University
関連論文
- Analysis of Apoptosis-related Factors and Apoptotic Cells in Lining Epithelium of Odontogenic Keratocysts
- Effects of Chronic Administration of Zonisamide, an Antiepileptic Drug, on Bone Mineral Density and Their Prevention With Alfacalcidol in Growing Rats
- Myoepithelioma with Collagenous Crystalloids in the Sublingual Gland : Report of a case
- Oral Manifestations of Chronic Graft-versus-host Disease : A clinicopathological study
- Multiple organ failure associated with extensive metastatic calcification in a patient with an intermediate state of human T lymphotropic virus type I (HTLV-I) infection : Report of an autopsy case
- A Case of Pleomorphic Adenoma with Formation of a Large Cyst : Histomorphometric analysis of tumor cells
- Immunolocalization of aromatase in human minor salivary glands of the lower lip with primary Sjogren's syndrome
- A case of the calcium pyrophosphate dihydrate (CPPD) deposition disease without condylar destruction of the temporomandibular joint
- Transfusion-Associated Graft-versus-Host Disease Diagnosed by Polymerase Chain Reaction Analysis of DNA Microsatellites : An Autopsy Case with Immunohistochemical Investigation
- Immunohistochemical Analysis of Vascular Endothelial Growth Factor (VEGF) Expression and Tumor Angiogenesis in Tongue Squamous Cell Carcinomas
- Immunohistochemical Study of CD1a-labeled Langerhans Cells and Anti-tumor Immune Cells in Oral Verrucous Carcinomas
- Expression of extracellular matrix molecules, MMPs and TIMPs in alveolar bone, cementum and periodontal ligaments during rat tooth eruption
- Chromogenic in situ hybridization analysis of HER-2/neu status in breast carcinoma : Application in screening of patients for trastuzumab (Herceptin^【○!R】) therapy
- Immunohistochemical Analysis of Benign Mixed and Mesenchymal Odontogenic Tumors
- Immunohistochemical Expression of Integrins and CD44 in Ameloblastomas
- Immunohistochemical Study on Apoptosis and Cell Proliferation in the Lining Epithelium of Thyroglossal Duct Cysts
- Age-Related Changes in Melanocyte Density of the Human Tongue - Histomorphometric Analysis of Japanese Autopsy Cases -
- Age-related changes in the expression of proliferating cell nuclear antigen and Lewis^Y antigen in human lingual epithelium
- The Three-Dimensional Architecture of the Cribriform Pattern in Adenoid Cystic Carcinoma of Salivary Gland Origin
- Phenytoin and Its Metabolite, 5-(4-Hydroxyphenyl)-5-Phenylhydantoin, Show Bone Resorption in Cultured Neonatal Mouse Calvaria
- Comparison of occlusal function in children with and without cleft lip and/or palate
- Oral findings and longitudinal observations in a patient with Ellis-van Creveld syndrome : A case report
- The dental management of latex allergy patients with spina bifida
- Age-related changes of pulpal blood flow in primary teeth measured by laser Doppler blood flowmetry
- Detection of the pulpal blood flow in primary teeth by laser Doppler flowmeter
- Case report of mammary analog secretory carcinoma of the parotid gland