Anti-obesity Effects of Juniperus chinensis Extract Are Associated with Increased AMP-Activated Protein Kinase Expression and Phosphorylation in the Visceral Adipose Tissue of Rats(Pharmacognosy)
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概要
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This study evaluates the protective effect of Juniperus chinensis hot water extract (JCE) against high-fat-diet (HFD)-induced obesity and its molecular mechanisms in the visceral adipose tissue of rats. JCE supplementation significantly lowered body weight gain, visceral fat-pad weights, blood lipid levels, and blood insulin and leptin levels of rats rendered obese by an HFD. Feeding with JCE significantly reversed the HFD-induced down-regulation of the epididymal adipose tissue genes implicated in adipogenesis, such as the peroxisome proliferator-activated receptors γ2 (PPARγ2), adipocyte protein 2 (aP2), sterol regulatory element binding protein Ic (SREBP1c), fatty acid synthase (FAS), and HMG-CoA reductase (HMGR), as well as those involved in uncoupled respiration, such as the uncoupling protein 2 (UCP2) and uncoupling protein 3 (UCP3). Dietary supplementation with JCE also reversed the HFD-induced decreases in the AMP-activated protein kinase (AMPK) and the acetyl-CoA carboxylase 2 (ACC2) expressions at both the mRNA and protein levels and restored the HFD-induced inhibitions in the AMPK and ACC2 phosphorylation, which are related to fatty acid β-oxidation, in the epididymal adipose tissue. This study reports, for the first time, that the JCE can have an anti-obesity effect in a rodent model with HFD-induced obesity through an enhanced gene transcription of the uncoupling protein as well as an elevated AMPK protein expression and phosphorylation in the visceral adipose tissue.
- 公益社団法人日本薬学会の論文
- 2008-07-01
著者
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Kim Ha
Department Of Life Sciences University Of Seoul
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Kim Ha
Department Of Chemical Engineering Hanyang University
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Kim Seung-jin
Department Of Chemistry Changwon National University
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Kim Seung-jin
Department Of Food And Nutrition Brain Korea 21 Project Yonsei University
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Jung Jin
Department Of Dermatology And Cutaneous Biology Research Institute Yonsei University College Of Medi
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Jung Jin
Department Of Food And Nutrition Brain Korea 21 Project Yonsei University
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Park Taesun
Department Of Food And Nutrition Brain Korea 21 Project Yonsei University
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Kim Ha
Department Of Biological Science And Engineering Korea Advanced Institute Of Science And Technology
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Jung Jin
Department Of Bioenergy Science And Technology Chonnam National University
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KIM Ha
Department of Life Sciences, University of Seoul
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