Binding Enhancements of Nicotinic Acid to Water-Soluble Zinc Porphyrins Based on Triple Attractions of Coordination, Coulomb, and CH-π Interactions

概要

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The binding of amines to artificial zinc-porphyrin receptors 1-4 was examined in basic aqueous solutions. For nicotinic acid and 3,5-dicarboxypyridine, substantial binding enhancements were observed compared to other amines with no π system or carboxyl group. This observation suggested that interligand attractions of Coulomb and CH-π interactions in addition to N-atom coordination can act effectively as recognition factors. The differences in the Coulomb interaction between carboxylate and sulfonate anions were also discussed.
公益社団法人日本薬学会の論文
2008-07-01