Novel Nortriterpenes from Phlomis umbrosa
スポンサーリンク
概要
- 論文の詳細を見る
We isolated 8 novel 28-noroleanane-derived spirocyclic triterpenoids with unusual skeleton structures, phlomisone (1), phlomistetraol A (2), phlomistetraol B (3), phlomistetraol C (4), phlomispentaol (5), phlomishexaol A (6), phlomishexaol B (7), and phlomisin (8), from the ethanol extract of Phlomis umbrosa rhizomes. Their structures were elucidated on the basis of spectroscopic methods, including 1D, 2D nuclear magnetic resonance (NMR), high-resolution mass spectrometry (HR-MS), and X-ray analyses. Compounds 1-3, 5, and 7 exhibited positive cytotoxic activities against the carcinoma cell lines Hela and L929 in vitro, and these bioactive data suggested that the C-18 and C-21 positions had oxygenated functions that can improve the activity of the compound.
- 公益社団法人日本薬学会の論文
- 2008-07-01
著者
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TAKAISHI Yoshihisa
Faculty of Pharmaceutical Sciences, University of Tokushima
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Duan Hong-quan
School Of Pharmaceutical Science Basic Medical Research Center Of Tianjin Tianjin Medical University
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Takaishi Yoshihisa
Faculty Of Pharmaceutical Sciences University Of Tokushima
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YAO Zhi
Department of Immunology, Tianjin Medical University
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Yao Zhi
Department Of Immunology Tianjin Medical University
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LIU Pu
School of Pharmaceutical Science, Basic Medical Research Center of Tianjin, Tianjin Medical Universi
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ZHANG Wen
School of Pharmaceutical Science, Basic Medical Research Center of Tianjin, Tianjin Medical Universi
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Liu Pu
School Of Pharmaceutical Science Basic Medical Research Center Of Tianjin Tianjin Medical University
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Zhang Wen
School Of Pharmaceutical Science Basic Medical Research Center Of Tianjin Tianjin Medical University
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Zhang Wen
School Of Pharmaceutical Sci. Basic Medical Res. Center Of Tianjin Tianjin Medical Univ.
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