Novel β-Lactam Antibiotics Synthesized by Amination of Catechols Using Fungal Laccase
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概要
- 論文の詳細を見る
Novel cephalosporins, penicillins, and carbacephems were synthesized by animation of catechols with amino-β-lactams like cefadroxil, amoxicillin, ampicillin and the structurally related carbacephem loracarbef using laccase from Trametes sp. All isolated monoaminated products inhibited the growth of several Gram positive bacterial strains in the agar diffusion assay, among them methicillin-resistant Staphylococcus aureus strains and vancomycin-resistant Enterococci. Observed differences in the cytotoxicity and in vivo activity in a "Staphylococcus-infected, immune suppressed mouse" model are discussed.
- 社団法人日本薬学会の論文
- 2008-07-01
著者
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Seefeldt Simone
Ganomycin Society Of Biomedical Research Ltd.
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MIKOLASCH Annett
Institute of Microbiology, Ernst-Moritz-Arndt-University Greifswald
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WURSTER Martina
Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald
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LALK Michael
Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald
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WITT Sabine
Ganomycin Society of Biomedical Research Ltd.
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HAMMER Elke
Interfacultary Institute for Genetics and Functional Genomics Ernst-Moritz-Arndt-University Greifswa
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SCHAUER Frieder
Institute of Microbiology, Ernst-Moritz-Arndt-University Greifswald
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JULICH Wolf-Dieter
Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald
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LINDEQUIST Ulrike
Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald
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Julich Wolf-dieter
Institute Of Pharmacy Ernst-moritz-arndt-university Greifswald
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Hammer Elke
Interfacultary Institute For Genetics And Functional Genomics Ernst-moritz-arndt-university
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Lalk Michael
Institute Of Pharmacy Ernst-moritz-arndt-university Greifswald
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Wurster Martina
Institute Of Pharmacy Ernst-moritz-arndt-university Greifswald
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Schauer Frieder
Institute Of Microbiology Ernst-moritz-arndt-university
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Mikolasch Annett
Institute Of Microbiology Ernst-moritz-arndt-university
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Lindequist Ulrike
Institute Of Pharmacy Ernst-moritz-arndt- University
関連論文
- Novel β-Lactam Antibiotics Synthesized by Amination of Catechols Using Fungal Laccase
- Novel Cephalosporins Synthesized by Amination of 2,5-Dihydroxybenzoic Acid Derivatives Using Fungal Laccases II
- Novel Penicillins Synthesized by Biotransformation Using Laccase from Trametes spec
- Synthesis of New N-Analogous Corollosporine Derivatives with Antibacterial Activity by Laccase-Catalyzed Amination