Novel Penicillins Synthesized by Biotransformation Using Laccase from Trametes spec

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概要

• 論文の詳細を見る

• Eight novel penicillins were synthesized by heteromolecular reaction of ampicillin or amoxicillin with 2,5-dihydroxybenzoic acid derivatives using a laccase from Trametes spec. All products inhibited the growth of several gram positive bacterial strains in the agar diffusion assay, among them methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci. The products protected mice against an infection with Staphylococcus aureus lethal to the untreated animals. Cytotoxicity and acute toxicity of the new compounds were neglectable. The results show the usefulness of laccase for the synthesis of potential new antibiotics. The biological activity of the new compounds stimulates intensified pharmacological tests.

• 社団法人日本薬学会の論文
• 2006-05-01

著者

• Seefeldt Simone

  Ganomycin Society Of Biomedical Research Ltd.

• MIKOLASCH Annett

  Institute of Microbiology, Ernst-Moritz-Arndt-University Greifswald

• LALK Michael

  Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald

• WITT Sabine

  Ganomycin Society of Biomedical Research Ltd.

• SCHAUER Frieder

  Institute of Microbiology, Ernst-Moritz-Arndt-University Greifswald

• JULICH Wolf-Dieter

  Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald

• LINDEQUIST Ulrike

  Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald

• NIEDERMEYER Timo

  Institute of Pharmacy, Ernst-Moritz-Arndt-University

• HAMMER Elke

  Institute of Microbiology, Ernst-Moritz-Arndt-University

• HESSEL Susanne

  Institute of Marine Biotechnology

• GESELL Manuela

  Institute of Marine Biotechnology

• Julich Wolf-dieter

  Institute Of Pharmacy Ernst-moritz-arndt-university Greifswald

• Hammer Elke

  Interfacultary Institute For Genetics And Functional Genomics Ernst-moritz-arndt-university

• Lalk Michael

  Institute Of Pharmacy Ernst-moritz-arndt-university Greifswald

• Hessel Susanne

  Institute Of Microbiology Ernst-moritz-arndt-university

• Schauer Frieder

  Institute Of Microbiology Ernst-moritz-arndt-university

• Mikolasch Annett

  Institute Of Microbiology Ernst-moritz-arndt-university

• Niedermeyer Timo

  Institute Of Pharmacy Ernst-moritz-arndt-university

• Lindequist Ulrike

  Institute Of Pharmacy Ernst-moritz-arndt- University

関連論文

• Novel β-Lactam Antibiotics Synthesized by Amination of Catechols Using Fungal Laccase
• Novel Cephalosporins Synthesized by Amination of 2,5-Dihydroxybenzoic Acid Derivatives Using Fungal Laccases II
• Novel Penicillins Synthesized by Biotransformation Using Laccase from Trametes spec
• Synthesis of New N-Analogous Corollosporine Derivatives with Antibacterial Activity by Laccase-Catalyzed Amination

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