P-62 イリジウム-サレン錯体を用いるシス選択的不斉シクロプロパン化(ポスター発表の部)

概要

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Asymmetric cyclopropanation is an important tool for organic synthesis. Although there have been many excellent reactions reported for trans-selective asymmetric cyclopropanation, only a few cis-selective ones have been reported and their substrate scopes are considerably limited. We were intrigued by the catalysis of complexes of iridium that is a group IX metal, since the complexes of cobalt and rhodium that belong to the same IX group have been proved to be efficient catalysts for asymmetric cyclopropanation. Thus, we synthesized a new Ir(salen) complex 4 bearing a σ-coordinated apical aryl group and examined asymmetric catalysis for cyclopropanation. Although the results are preliminary ones, the Ir complex showed several unique catalyses. For example, the reaction of internal cis-di and tri-substituted olefins showed high cis- and enantio-selectivity, albeit with insufficient chemical yield. The detailed results so far obtained are discussed in this paper.
2006-09-15