1 ホオズキ属植物のステロイド化合物フィサリン類の相互関係、構造変換および抗腫瘍活性について(口頭発表の部)

概要

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Physalins are 13,14-seco-16,24-cyclosteroidal constituents of Physalis plants. Physalin Q (11) possessing endoperoxy structure was isolated from Physalis alkekengi var. francheti. The reported structures of physalins E, H (13), and K (9) were revised. According to the partial structure around C(27) physalins are classified into three types I-III, and interconversion reaction was found between the physalins of types I and II, e.g., physalins B (1) and C (6). Interrelationships among known physalins were suggested. Physalins F (2) and J (14), which were epoxidation products of physalin B, were actually converted to physalins D (15), H, I (16), etc. Transformation by means of photosensitized oxygenation was also observed, e.g., physalin B to physalin K. Activated charcoal-mediated hydroxylation at C(25) was found affording new physalin analogs. Physalins underwent benzilic acid rearrangement-type skeletal conversion to yield compounds possessing neophysalin skeleton. Some of these physalins and their derivatives exhibited in vitro cytotoxic activity against HeLa cells.
天然有機化合物討論会の論文
1994-09-20