39 細胞保護作用を有する新規化合物rumbrin,thiazohalostatinの構造研究(口頭発表の部)

概要

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In the course of our screening program for cytoprotective substances of microbial origin, we have isolated two new compounds named rumbrin and thiazohalostatin. Rumbrin was produced by a fungi identified as Auxarthon umbrinum. The molecular formula was determined as C_<20>H_<20>NO_3Cl by high resolution FAB-MS and the structure was elucidated by a variety of two-dimentional NMR tecniques as shown in Fig. 2. Furthermore, the structure was confirmed by 2D INADEQUATE experiment using [1,2-^<13>C_2] acetate labeled rumbrin. Thiazohalostatin was produced by a actinomycete identified as Actinomadura sp., The molecular formula was determined as C_<20>H_<25>N_2O_4SCl_3 by high resolution FAB-MS and elemental analyses. The structure was elucidated by the NMR spectral analyses on thiazohalostatin and its derivatives (trimethylthiazohalostatin and tribromo analog of thiazohalostatin) as shown in Fig. 5. Rumbrin and thiazohalostatin showed cytoprotective and antioxidant activities as shown in Table 5.
天然有機化合物討論会の論文
1993-09-10