42 生理活性イソプレノイド生合成阻害物質の研究
スポンサーリンク
概要
- 論文の詳細を見る
The inhibitors of biologically active isoprenoid biosyntheses are not only useful as a tool of the study on the biosynthetic pathways, but also used as agricultural chemicals or medicines. This paper will report total synthesis of diplodialide-A which is a steroid hydroxylase inhibitor and screening study on the inhibitors of gibberellin biosynthesis. (I) Total Synthesis of Diplodialide-A The key intermediate(6) was prepared by the reaction of the dianion of ethyl acetoacetate with the bromibe(5). The seco acid(8) was transformed to the thiol ester(9) and its dilute xylene solution was refluxed under argon to give (10). The introduction of a double bond to the γ-position of the β-keto-lactone(11) has been performed by the γ-selenenylation of the dianion of (11) follewd by selenoxide elimination. Both antipodes of (±)-diplodialide-A were synthesized by GLC separation of the diastereoisomeric mixture of the acetal, (15) and (16), and the following reactions. (II) Inhibitors of Gibberellin Biosynthesis Resuspended mycelium of G. fujikuroi was used for tests. In our screening study of the inhibitors of gibberellin biosynthesis, 1-geranylimidazole and 1-decylimidazole showed inhibition of GA_3 biosynthesis at 12.5ppm(66% inhibition) and 6.25ppm(74% inhibition), respectively. These compounds inhibited C-19 oxygenation of (-)-kaurene and kauren-19-ol, but not the transformation of kaurenoic acid to gibberellin.
- 天然有機化合物討論会の論文
- 1978-08-22
著者
関連論文
- 29.光照射によるイネ葉身傾斜・葉身展開と内生ブラシノステロイドの関係 (第20回大会研究発表抄録)
- 29 光照射によるイネ葉身傾斜・葉身展開と内生ブラシノライドの関係
- 17 Brassinosteroidsの極性的イネ葉身屈曲活性とコムギ葉身展開活性
- 10 イネのラミナジョイントテスト : Brassinosteroidsの微量定量生物検定法
- 29 Brassinolideの植物生理活性(第一報)
- 42 生理活性イソプレノイド生合成阻害物質の研究
- イソプレノイド生合成阻害物質(化学の窓)
- 19 Shiromodiol-Diacetateの絶対構造
- 1 カミエビ葉中の殺虫性アルカロイド,Cocculolidineの構造
- 10 Brassinolide関連化合物のラミナジョイント屈曲活性 : 側鎖構造と活性との相関
- 新しい植物生長調節物質Brassinolide
- 5 Brassinolide関連化合物の合成と生理活性
- 15 人工基貭からのジベレリン関連化合物の微生物生産
- 11. ジベレリン生合成阻害物質の研究
- A205 ヒメトビウンカのステロール(代謝等)