輸液ポンプ使用時のパクリタキセル注射溶液の点滴速度に影響する要因について

概要

論文の詳細を見る
We examined the influence of the type of infusion pump and the physical properties (viscosity and surface tension) of paclitaxel (PTX) solution on the infusion rate of PTX. We diluted PTX to make 5% glucose injection solutions having a volume of 250 mL and set the infusion rate of the infusion pumps at 250 mL/h. The infusion rate of a PTX solution was almost the same as the rate setting when a flow rate control type infusion pump was used but the infusion rate of a PTX solution was slower with a drip sensor control type infusion pump and infusion took about 1.7 times as long as the rate setting. We therefore recommend using a flow rate control type infusion pump. When infusing the weekly dosage of PTX using a drip sensor control infusion pump, we realized that infusion of the PTX solution could be finished within the scheduled time by setting the infusion rate 1.7 times faster. Further, our results indicated that the factor delaying the infusion of the PTX solution with the drip sensor control type infusion pump was not the increase in viscosity of the PTX solution but a drop in surface tension due to the surfactant in the PTX solution.
日本医療薬学会の論文
2008-05-10