Evaluation of Anti-HSV-2 Activity of Gallic Acid and Pentyl Gallate(Medicinal Chemistry)

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概要

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• The synthetic n-alkyl esters of gallic acid, also known as gallates, are widely employed as antioxidants by food and pharmaceutical industries. Besides the antioxidant activity, other biological activities have been described for this group of molecules, mainly anticancer, antibacterial and antifungal properties. In the present study, the anti-herpes simplex virus (HSV)-2 activity of gallic acid and pentyl gallate was evaluated followed by the determination of the site of antiviral activity of these compounds. Our results demonstrated that both compounds reduced HSV-2 replication in a concentration-dependent manner when either incubated with the virus prior to the addition of the mixture to cells, or added to and incubated with cells after their infection. In summary, the anti-HSV-2 activity of gallic acid and pentyl gallate was ascribed to their virucidal effect on virus particles, a change that was likely accompanied by partial inhibition of the virus attachment to cells and its subsequent cell-to-cell spread activity. This suggests that these compounds can be regarded as promising candidates for development as topical anti-HSV-2 agents.

• 公益社団法人日本薬学会の論文
• 2008-05-01

著者

• Yunes Rosendo

  Laboratory Of Synthesis And Structure-relationship Department Of Chemistry Universidade Federal De S

• Simoes Claudia

  Laboratory Of Applied Virology Department Of Pharmaceutical Sciences Universidade Federal De Santa C

• Kratz Jadel

  Laboratory Of Applied Virology Department Of Pharmaceutical Sciences Universidade Federal De Santa C

• ANDRIGHETTI-FROHNER Carla

  Laboratory of Applied Virology, Department of Pharmaceutical Sciences, Universidade Federal de Santa

• LEAL Paulo

  Laboratory of Synthesis and Structure-Relationship, Department of Chemistry, Universidade Federal de

• NUNES Ricardo

  Laboratory of Synthesis and Structure-Relationship, Department of Chemistry, Universidade Federal de

• TRYBALA Edward

  Department of Clinical Virology, Goteborg University

• BERGSTROM Tomas

  Department of Clinical Virology, Goteborg University

• BARARDI Celia

  Department of Microbiology and Parasitology, Universidade Federal de Santa Catarina, UFSC

• Leal Paulo

  Laboratory Of Synthesis And Structure-relationship Department Of Chemistry Universidade Federal De S

• Nunes Ricardo

  Laboratory Of Synthesis And Structure-relationship Department Of Chemistry Universidade Federal De S

• Barardi Celia

  Department Of Microbiology And Parasitology Universidade Federal De Santa Catarina Ufsc

• Trybala Edward

  Department Of Clinical Virology Goteborg University

• Andrighetti-frohner Carla

  Laboratory Of Applied Virology Department Of Pharmaceutical Sciences Universidade Federal De Santa C

• Bergstrom Tomas

  Department Of Clinical Virology Goteborg University

関連論文

• In Vitro Antiviral Activity of Marine Sponges Collected Off Brazilian Coast(Pharmacognosy)
• Evaluation of Anti-HSV-2 Activity of Gallic Acid and Pentyl Gallate(Medicinal Chemistry)

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