諸種臟器越幾斯の循環器に及ぼす影響 : 第四報 耳下腺越幾斯の家兎血壓並に脈搏に及ぼす影響
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The writer studied the influence of the injection of protein-eliminated extract from parotid gland upon rabbit's blood pressure and pulse systematically, over a long period, by means of the bloodless method. The extract was made in such a condition that 1 cc corresponded to 10 gr of the raw organ. 1) No changes worth noting were observed by intravenous injection of 0.1 cc per kg in blood pressure, pulse curve amplitude and pulse rate. 2) By intravenous injection of 0.25 cc per kg, changes were found in blood pressure and pulse curve amplitude. 3) By intravenous injection of 0.5 cc per kg relatively remarkable changes were produced. Maximal blood pressure fell by 30 mm Hg on the average immediately after injection, and 60 minutes after descended by 26 mm Hg on the average compared with the original value. The degree of the change in minimal blood pressure was small compared with that of maximal blood pressure. Pulse curve amplitude decreased by 2.1 mm on the average immediately after injection, and in 60 minutes decreased by 2.5 mm compared with the original value. These changes returned almost to the original values after 24 hours. 4) By subcutaneous injection of 0.5 cc per kg, changes were later in appearance and slighter in degree compared with those by intravenous injection. 5) From the above results the author can perceive that a substance which causes the blood pressure to fall is contained in the extract of parotid gland.
- 社団法人日本循環器学会の論文
- 1937-09-01
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