236 脳組織内の薬物動態解析における入力関数の誤差の影響

概要

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Positron emission tomography (PET) imaging with C-11 doxepin, a histamine H1 receptor ligand, has been used to evaluate sedative side effect of antihistamine drugs on human subjects by measuring the receptor occupancy (RO) that reflects the adverse effect. The RO is obtained from the binding potential (BP) of the C-11 doxepin following the administration of the drug and that in the baseline. BP is usually derived from the measured distribution volume (DV) in the cerebral cortex and in the cerebellum. Although accurate estimation of the input function is crucial to estimation of DV and BP, sequential arterial blood sampling with metabolite analysis is not practical, and standard input function with one-point venous blood sampling is often adopted. The purpose of the study is to evaluate the effect of the error in the input function on the estimation of the DV, BP, and RO.
社団法人日本機械学会の論文
2007-09-25