Solubility Prediction of Paracetamol in Water-Ethanol-Propylene Glycol Mixtures at 25 and 30℃ Using Practical Approaches
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概要
- 論文の詳細を見る
The solubility of paracetamol in water-ethanol-propylene glycol binary and ternary mixtures at 25 and 30℃ was determined using flask shake method. The generated data extended the solubility database for further computational investigations and also was used to assess the prediction capability of the Jouyban-Acree model. A new version of the model was proposed for modeling the solubility data in water-cosolvent mixtures with the cosolvent concentration of <50% which is required in pharmaceutical formulations. The accuracy of the predicted solubilities was evaluated by the mean percentage deviation (MPD) between the predicted and experimental solubilities. The overall MPD of the Jouyban-Acree model and the log-linear model of Yalkowsky for the entire composition range of the cosolvents were 11.0±8.7 and 55.4±17.8%, respectively; the corresponding values for the predicted solubilities in mixtures having a cosolvent concentration of <50% were 12.0±9.1 and 22.0±11.0%.
- 公益社団法人日本薬学会の論文
- 2008-04-01
著者
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JOUYBAN Abolghasem
Faculty of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences
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Jouyban Abolghasem
Faculty Of Pharmacy And Drug Applied Research Center Tabriz University Of Medical Sciences
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Jouyban Abolghasem
Faculty Of Pharmacy And Drug Applied Research Center Tabriz University Of Medical Sciences:kimia Res
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Acree Jr.
Department Of Chemistry University Of North Texas
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AZARMIR Olduz
Pharmaceutical Nanotechnology Research Center, Tabriz University of Medical Sciences
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MIRZAEI Shahla
Biotechnology Research Center, Tabriz University of Medical Sciences
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HASSANZADEH Davoud
Faculty of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences
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GHAFOURIAN Taravat
Medway School of Pharmacy, Central Ave., Universities of Kent and Greenwich
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NOKHODCHI Ali
Medway School of Pharmacy, Central Ave., Universities of Kent and Greenwich
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Hassanzadeh Davoud
Faculty Of Pharmacy And Drug Applied Research Center Tabriz University Of Medical Sciences
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Ghafourian Taravat
Medway School Of Pharmacy Central Ave. Universities Of Kent And Greenwich
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Azarmir Olduz
Pharmaceutical Nanotechnology Research Center Tabriz University Of Medical Sciences
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Mirzaei Shahla
Biotechnology Research Center Tabriz University Of Medical Sciences
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Nokhodchi Ali
Medway School Of Pharmacy Central Ave. Universities Of Kent And Greenwich
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