トルエン,キシレン,エチルベンゼンの尿中代謝物6種の同時測定法とグラビア印刷作業者での生物学的モニタリング

概要

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For the biological monitoring of exposure to solvent composed of toluene, xylene, and ethyl-benzene used in a printing factory with gravure machines, we developed a HPLC method for the simultaneous determination of urinary metabolites of this solvent, i.e. hippuric acid, o-, m-, and p-methylhippuric acid, mandelic acid and phenylglyoxylic acid. Except for phenylglyoxylic acid, urinary concentrations of the metabolites determined by the present method correlated well with the air concentrations of the respective solvent components. Hence the present method is useful in monitoring solvent exposure. In 91 workers of the printing factory and 53 control subjects, we also determined the concentrations of some phenolic metabolites and confirmed that o-cresol is a useful indicator for monitoring toluene exposure.
社団法人日本産業衛生学会の論文
1989-01-20