単純せん断流中における脂質二分子膜ベシクルの挙動 : 第1報,Tank-treading運動における安定傾き角と膨潤率の関係の検証(流体工学,流体機械)

概要

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Deformation and motion of lipid bilayer vesicles in a simple shear flow have been observed by phase contrast microscopy. We construct a rotating-cylinder apparatus, which can create a simple shear flow with steady shear rates. Vesicles are prepared from 1,2-dioleoyl-sn-glycero-3-phospho-choline by the gentle hydration method. In our observation, vesicles are deformed to steady ellipsoidal shapes and show constant orientations with θ_1, which is the angle between the major axis and the flow direction. It is confirmed that the relationship between the θ_1 and the swelling ratio (volume/surface ratio) S_w agrees quantitatively with the experimental result of Abkarian & Viallat [Biophys. J., Vol. 89, 1055 (2005)], which is obtained with vesicles in wall bounded shear flows. It is also confirmed that our result agrees with a theoretical analysis of Keller & Skalak [J. Fluid Mech., Vol. 120, 27 (1982)] and other numerical simulations. They are based on different membrane models, which are supposed to cause the different local behaviors of the membrane. This agreement indicates that the local membrane behavior does not have significant influence on θ_1.
一般社団法人日本機械学会の論文
2008-03-25