Adrenalineの門脈壓に及ぼす影響に就て
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概要
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The effects of adrenaline on the volume of the liver and the portal pressure were studied. All experiments were carried out on dogs under urethane anaesthesia. The changes of the carotid blood pressure, the portal pressure, the blood pressure in the thoracic vena cava and of the volume of the liver were recorded on a photographic kymograph, and in this way were obtained the following results. 1) The changes in hapatic volume occurred simultaneously with the rise of arterial pressure: when 1 : 10000 solution of adrenaline was injected into the portal vein, the hepatic volume decreased to maximal degrees at the peaks of the rising arterial pressure (Fig. 2), and when adrenaline was injected into the femoral vein, the maximal decrease in hepatic volume occurred in the lowest stage of arterial pressure (Fig. 1) 2) The change in portal pressure was not parrallel to the change in hepatic volume. In systemic venous injection of adrenaline, an initial rise and secondary rise of portal pressure occured. (Fig. 1). In portal in jections, one marked rise in portal pressure was observed (Fig. 2), but after the occlusion of the hepatic artery, the primary and secondary rises in portal pressure were also observed by portal injection as shown in Fig. 3, B. 3) It is known from the following experiment that the chief cause of a rise in the portal pressure under adrenaline does not depend only upon the contraction of the hepatic blood vessels. The experiment employing Eck's fistula proved that the primary and secondary rises of portal pressure by injection of adrenaline were present even though there was no accompanying slow heart beat. (Fig.4, A and B) 4) The initial rise in portal pressure was due to the constrkction of the hepatic blood vessels plus the secondary dffects of the rise in arterial pressure. The secondary rise of portal pressure may be attributed to the constriction of the hepatic blood vessels plus the increased inflow in the portal system. 5) The blood flow in the hepatic artery is related to the maintenance of the portal pressure. When hepatic artery is occluded, the initial rise in portal pressure by injection of adrenaline was followed by a marked fall of the portal pressure (Fig. 3, A and B).
- 社団法人日本循環器学会の論文
- 1954-05-20