The Flavouring Phytochemical 2-Pentanone Reduces Prostaglandin Production and COX-2 Expression in Colon Cancer Cells(Pharmacognosy)

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概要

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• Many phytochemicals found in the diet may prevent colon carcinogenesis by affecting biochemical processes in the colonic mucosa. Inflammation and subsequent elevation of the enzyme cyclooxygenase-2 (COX-2) are two such factors involved in the development of colon cancer, and inhibition of these processes could be important targets for chemoprevention. We have previously shown COX-2 inhibitory activity locally in the colon; e.g. in human fecal water from a group of vegetarians. In this study we focus on 2-pentanone, a frequently occurring compound in common foods such as banana and carrot. The aim was to study the inhibitory effects on prostaglandin production and COX-2 protein expression in tumour necrosis factor-α stimulated colon cancer cells (HT29) by radioimmunoassay and Western blotting. 2-Pentanone inhibited both prostaglandin production and COX-2 protein expression in human colon cancer cells. A concentration of 400 μmol/1 2-pentanone inhibited the prostaglandin production by 56.9±12.9% which is in the same range as the reference compound NS398 (59.8±7.6%). The two highest concentrations of 2-pentanone were further analyzed by Western blot, and 400 μmol/l and 200 μmol/l 2-pentanone resulted in a 53.3±9.6% and ±27.1% reduction of the COX-2 protein levels respectively. Further studies on flavouring compounds, for example 2-pentanone, as colon cancer chemopreventives would be very valuable, and such results may contribute to future dietary recommendations.

• 公益社団法人日本薬学会の論文
• 2008-03-01

著者

• Karlsson Pernilla

  Division Of Medical Nutrition Department Of Biosciences And Nutrition Karolinska Institutet

• Rafter Joseph

  Division Of Medical Nutrition Department Of Biosciences And Nutrition Karolinska Institutet

• PETTERSSON Jenny

  Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University

• BOHLIN Lars

  Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University

• GORANSSON Ulf

  Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University

• Bohlin Lars

  Division Of Pharmacognosy Department Of Medicinal Chemistry Biomedical Centre Uppsala University

• Goransson Ulf

  Division Of Pharmacognosy Department Of Medicinal Chemistry Biomedical Centre Uppsala University

• Bohlin Lars

  Division Of Pharmacognosy Department Of Medicinal Chemistry Uppsala University

• Pettersson Jenny

  Division Of Pharmacognosy Department Of Medicinal Chemistry Biomedical Centre Uppsala University

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