Constituents of Hypericum laricifolium and Their Cyclooxygenase (COX) Enzyme Activities
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概要
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Investigation of the aerial parts of the medicinal plant Hypericum laricifolium led to the isolation of two new natural products, hentriacontanyl caffeate (1a), nonacosanyl caffeate (1b). In addition, stigmasterol, β-sitosterol, 3-epi-betulinic acid (2), caffeic acid (3), ferulic acid, docosanol, p-hydroxybenzoic acid, 3,4-dimethoxy benzoic acid, quercetin (4), quercetin-3-O-galactoside (5), quercetin-3-O-rutinoside (6), quercetin-3-O-rhamnoside (7), quercetin-3-O-glucuronide (8) and shikimic acid were also isolated. The structures were determined by 1D- and 2D-NMR, mass spectrometry, and chemical transformations. The anti-inflammatory effects of the isolated compounds were discussed briefly.
- 公益社団法人日本薬学会の論文
- 2003-12-01
著者
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BOHLIN Lars
Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University
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Bohlin Lars
Division Of Pharmacognosy Department Of Medicinal Chemistry Biomedical Centre Uppsala University
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EL-SEEDI Hesham
Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University
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RINGBOM Therese
Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University
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TORSSELL Kurt
Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University
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Ringbom Therese
Division Of Pharmacognosy Department Of Medicinal Chemistry Biomedical Centre Uppsala University
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Torssell Kurt
Division Of Pharmacognosy Department Of Medicinal Chemistry Biomedical Centre Uppsala University
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El-seedi Hesham
Division Of Pharmacognosy Department Of Medicinal Chemistry Biomedical Centre Uppsala University
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