Allopurinol Gel Mitigates Radiation-induced Mucositis and Dermatitis
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概要
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It has not been verifiied whether allopurinol application is beneficial in decreasing the severity of radiation-induced oral mucositis and dermatitis. Rats were divided into 4 groups and received 15 Gy irradiation on the left whisker pad. Group 1 received only irradiation. Group 2 was maintained by applying allopurinol/carrageenan-mixed gel (allopurinol gel) continuously from 2 days before to 20 days after irradiation. Group 3 had allopurinol gel applied for 20 days after radiation. Group 4 was maintained by applying carrageenan gel continuously from 2 days before to 20 days after irradiation. The intra oral mucosal and acute skin reactions were assessed daily using mucositis and skin score systems. The escape thresholds for mechanical stimulation to the left whisker pad were measured daily. In addition, the irradiated tissues at the endpoint of this study were compared with naive tissue. Escape threshold in group 2 was significantly higher than that in group 1, and mucositis and skin scores were much improved compared with those of group 1. Concerning escape threshold, mucositis and skin scores in group 3 began to improve 10 days after irradiation. Group 4 showed severe symptoms of mucositis and dermatitis to the same extent as that observed in group 1. In the histophathological study, the tissues of group 1 showed severe inflammatory reactions, compared with those of group 2. These results suggest that allopurinol gel application can mitigate inflammation reactions associated with radiation-induced oral mucositis and dermatitis.
- 日本放射線影響学会の論文
- 2008-01-15
著者
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OKUMURA Hayato
Department of Mechanical Engineering, Nagaoka University of Technology
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KITAGAWA Junichi
Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University
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MATSUMOTO Shigeji
Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University
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Okumura Hayato
Department Of Oral And Maxillofacial Radiology Nippon Dental University School Of Life Dentistry At
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Shibata Akihiko
Nippon Dental University Hospital Oral And Maxillofacial Surgery:center For Drug Delivery Research T
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NASU Masanori
Research center of Odontology, Nippon Dental University, School of Life Dentistry at Tokyo
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MAKINO Kimiko
Faculty of Pharmaceutical Sciences, Tokyo University of Science
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TERADA Hiroshi
Center for Drug Delivery Research, Tokyo University of Science
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Nasu Masanori
Research Center For Odontology The Nippon Dental University School Of Life Dentistry
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Nasu Masanori
Research Center Of Odontology Nippon Dental University School Of Life Dentistry At Tokyo
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Makino Kimiko
Faculty Of Pharmaceutical Sciences Tokyo University Of Science:center For Drug Delivery Research Tok
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Matsumoto Shigeji
Department Of Physiology Nippon Dental University School Of Life Dentistry At Tokyo
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Terada Hiroshi
Center For Drug Delivery Research Tokyo University Of Science:institute Of Colloid And Interface Sci
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Makino Kimiko
Faculty Of Pharmaceutical Sciences And Institute Of Colloid And Interface Science Science University
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Kitagawa Junichi
Department Of Physiology Nippon Dental University School Of Life Dentistry At Tokyo
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