A Novel Approach for Screening of New Anti-Helicobacter pylori Substances(Microbiology)
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概要
- 論文の詳細を見る
Gastric mucosal cell-derived L-lactic acid strongly enhances proliferation of Helicobacter pylon, and may contribute to the long-term colonization of H. pylori in the stomach. Therefore it is assumed that inhibitory substances active against L-lactic acid-dependent growth of H. pylori will be useful candidates as novel therapeutic agents for H. pylori infection. In this study, we developed a new assay system for screening anti-H. pylon substances, and baicalein and glycyrrhetinic acid were found as potent inhibitory substances against L-lactic aciddependent H. pylori growth but not L-lactic acid-independent growth. The newly developed assay system described in this study also may facilitate the development of novel therapeutic agents for H. pylori infection.
- 2008-01-01
著者
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YAMADA Haruki
The Kitasato Institute
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Matsumoto Tsukasa
The Kitasato Institute For Life Sciences And Graduate School Of Infection Control Sciences Kitasato
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Yamada Haruki
The Kitasato Institute For Life Sciences And Graduate School Of Infection Control Sciences Kitasato
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TAKAHASHI Tetsufumi
Graduate School of Pharmaceutical Sciences, Kitasato University
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Takahashi Tetsufumi
Graduate School Of Pharmaceutical Sciences Kitasato University
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