A Convenient and Stereoselective Synthesis of 11Z-3,4-Didehydroretinal by Horner-Emmons Reaction Using Diphenyl Phosphonate
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概要
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A convenient synthesis of 3,4-didehydroretinal was developed. The Horner-Emmons reaction between 3,4-didehydro-β-ionone and diphenyl phosphonate in the presence of crown ether gave the retinonitrile as an isomeric mixture, in which the newly produced double bond was predominantly 11Z-form. After separation of the 11Z-form retinonitrile, it was converted into the corresponding retinal in good yield without isomerization of the double bonds.
- 社団法人日本薬学会の論文
- 2008-01-01
著者
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ITO Masayoshi
Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu Universi
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Wada Akimori
Department Of Organic Chemistry For Life Science Kobe Pharmaceutical University
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WANG Fei
Department of Organic Chemistry for Life Science, Kobe Pharmaceutical University
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Wang Fei
Department Of Forest Products Faculty Of Agriculture Kyushu University
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Ito Masayoshi
Department Of Organic Chemistry For Life Science Kobe Pharmaceutical University
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Wang Fei
Department Of Cardiovascular Surgery China-japan Friendship Hospital
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Wang Fei
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
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