ラット後躯自己血液潅流標本における血管拡張反応の薬理学的特性

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Perfusion pressure of pump-perfused hindquarters of the Wistar rats anesthetized with pentobarbital was measured. A dilator response was elicited by i.v. bolus injection of norepinephrine or by stimulation of the lumbar sympathetic nerves with pulses of 0.03 msec and shorter; longer pulses evoked a biphasic constrictor and dilator responses. The vasodilator responses were abolished by i.v. hexamethonium, indicative of their neurogenic nature. They were diminished by i.a. infusion of H1-antihistaminics, d, 1-chlorpheniramine and tripelennamine, but not by pyrilamine. However, d, 1-chlorpheniramine and tripelennamine, but not pyrilamine, are known to inhibit norepinephrine uptake, and were mimicked by cocaine in their antidilator activity. H2-antagonists, metiamide and cimetidine, given i.a. singly or in combination with pyrilamine had no such effect, not did i.a. atropine or propranolol. The latter two agents and H1- and H2-antagonists blocked the dilator responses to i.a. acetylcholine, isoprenaline and histamine, respectively. The neurogenic vasodilation was, therefore, probably not mediated by the H1- or H2-histaminic, muscarinic, or β-adrenergic receptors.
帯広畜産大学の論文
1996-06-26