Effects of Vanadate on Glucose Metabolism in the Lens of Rats with Streptozotocin-Induced Diabetes

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The effects of vanadate, an oxidized form of vanadium, on glucose metabolism in the lens of diabetic rats were studied. Five-week-old male Sprague-Dawley rats were rendand diabetic with intraperitoneal injection of streptozotocin (50 mg/kg). One week later, the diabetic rats were given 0.2 g/L NaV03-5g/L NaCl solution in drinking water ad libitum for 2 weeks and the biochemical parameters in their lenses were determined. Blood glucose levels significantly decreased in the vanadate-treated diabetic rats (diabetic, vanadate-treated group: DV group), compared with the diabetic rats given no vanadate (diabetic, control group: D group). In the DV group, a significant decrease was observed in lens fructose content compared with the D group. Lens ketohexokinase activity tended to be higher and lens aldolase activity was significantly higher in the DV group than in the D group. These results indicate that vanadate accelerates the metabolic reaction from the sorbitol pathway to glycolysis.
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