Biotransformation of Bile Acids by Bacteroides sp. Strain T-40 Isolated from Human Microflora

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概要

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• The effects of Bacteroides sp. strain T-40 isolated from human feces on the biotransformation of bile acids were examined in an anaerobic culture system. Bacteroides sp. T-40 oxidized cholic acid (CA) and chenodeoxycholic acid (CDCA) to 3α,12α-dihydroxy-7-oxo-5β-cholanoic acid and 3α-hydroxy-7-oxo-5β-cholanoic acid, and reduced these oxo-bile acids to CA and CDCA, respectively. However, the reduction activities were lower than the oxidation activities. Hyocholic acid was dehydrogenated, but to a lesser extent than CA or CDCA. On the other hand, α-muricholic acid, which has a hydroxyl group at the position of 7α, was not dehydrogenated. Glycocholic acid was converted to free 3α,12α-dihydroxy-7-oxo-5β-cholanoic acid but any glycine conjugated 7-oxo product was not detected. These data indicate that Bacteroides sp. T-40 possesses bile acid hydrolase and 7α-hydroxysteroid dehydrogenase, by which conjugated bile acids are initially deconjugated, and then undergo oxidization of the 7α-hydroxy group.

• 鳥取大学の論文

著者

• Ogura Yoshio

  Division Of Medical Biochemistry Department Of Pathophysiological And Therapeutic Science School Of

• Ogura Yoshio

  Division Of Medical Biochemistry Department Of Pathophysiological And Therapeutic Science School Of

関連論文

• Aerobic and Anaerobic Biotransformation of Bile Acids by Escherichia coli (II) : No Conversion of α-Muricholic Acid by 7α-Hydroxysteroid Dehydrogenase of E. coli
• Analysis of Bile Acids in Urine Specimens from Healthy Humans: Detrmination of Several Bile Acids with β-Hydroxyl and Carbonyl Groups
• Aerobic and Anaerobic Biotransformation of Bile Acids by Escherichia coli (I)
• Aerobic and Anaerobic Biotransformation of Bile Acids by Escherichia coli (III)
• Biotransformation of Bile Acids by Bacteroides sp. Strain T-40 Isolated from Human Microflora

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