Effectiveness of Reporting System for Carbapenem Antibiotics in Restricting Their Use

概要

論文の詳細を見る
We designed a reporting system for the use of carbapenem antibiotics at Fuchu Hospital in order to restrict their use. We also examined the effect of the system on the number of vials of antibiotics used from December 2002 to November 2004 and compared the total amount of antibiotics used before and after introducing the system. In our hospital, a large amount of panipenem is used, while the use of imipenem is limited. The antimicrobial use density (AUD) of panipenem decreased significantly from 9.85 to 7.59 due to the introduction of the reporting system (p<0.01) while that of imipenem decreased from 0.06 to 0.04. Therefore, the introduction of the system significantly influenced the use of panipenem but not that of imipenem. Following its introduction, the rate of occurrence of panipenem-resistant Pseudomonas aeruginosa decreased from 41.38% to 24.00% (p<0.001) while that of imipenem-resistant P. aeruginosa decreased from 18.23% to 10.91% (p<0.01). We therefore conclude that the reporting system brought about an apparent reduction in the occurrence of carbapenem-resistant P. aeruginosa.
日本医療薬学会の論文
2007-10-10