Urinary Excretion Profiles of 5-Methoxy-N, N-diisopropyltryptamine and Its Relevant Metabolites in Humans
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概要
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5-Methoxy-N, N-diisopropyltryptamine (5-MeO-DIPT), a psychotomimetic tryptamine derivative, and its relevant metabolites have been determined in eleven urine specimens from six 5-MeO-DIPT users, and their excretion profiles have been investigated by gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS). Three metabolites, 5-hydroxy-N, N-diisopropyltryptamine (5-OH-DIPT), 6-hydroxy-5-methoxy-N, N-diisopropyltryptamine (6-OH-5-MeO-DIPT), and 5-methoxy-N-isopropyltryptamine (5-MeO-NIPT) were determined in the urine specimens. Urinary conjugated metabolites, both sulfates and glucuronides of 5-OH-DIPT and 6-OH-5-MeO-DIPT, were hydrolyzed completely by the use of Helix pomatia sulfatase/β-glucuronidase. Degradation of 6-OH-5-MeO-DIPT during incubation for hydrolysis was successfully prevented by the addition of ascorbic acid. The hydrolysis treatment increased the detection amounts of 5-OH-DIPT and 6-OH-5-MeO-DIPT in most of the specimens, and the increase in 6-OH-5-MeO-DIPT was more drastic than that in 5-OH-DIPT. The concentrations of 5-MeO-DIPT (<1.7μg/ml) and 5-MeO-NIPT (<3.5μg/ml) were lower than those of 5-OH-DIPT (0.01-47μg/ml) and 6-OH-5-MeO-DIPT (<69μg/ml) detected after hydrolysis (the totals of their free and conjugated forms). These metabolites were detectable over longer periods post intake than the parent drug ; 35hr for 5-MeO-DIPT, 80hr for 5-OH-DIPT, and 60hr for 6-OH-5-MeO-DIPT and 5-MeO-NIPT.
- 公益社団法人日本薬学会の論文
- 2007-10-01
著者
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Shima Noriaki
Forensic Science Laboratory, Osaka Prefectural Police Headquarters
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TSUTSUMI Hiroe
Forensic Science Laboratory, Osaka Prefectural Police Headquarters
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NISHIKAWA Mayumi
Forensic Science Laboratory, Osaka Prefectural Police Headquarters
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Tsutsumi Hiroe
Forensic Science Laboratory Osaka Prefectural Police Headquarters
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Tsuchihashi Hitoshi
Forensic Science Laboratory Osaka Prefectural Police H.q.
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KAMATA Hiroe
Forensic Science Laboratory, Osaka Prefectural Police Headquarters
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Kamata Hiroe
Forensic Science Laboratory Osaka Prefectural Police Headquarters
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Katagi Munehiro
Forensic Science Laboratory Osaka Prefectural Police H.q.
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Nishikawa Mayumi
Forensic Science Laboratory Osaka Prefectural Police Headquarters
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Nishikawa Mayumi
Forensic Science Laboratory Osaka Prefectural Police H.q.
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Kamata Tooru
Forensic Science Laboratory Osaka Prefectural Police Headquarters
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MIKI Akihiro
Forensic Science Laboratory, Osaka Prefectural Police Headquarters
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Miki Akihiro
Forensic Science Laboratory Osaka Prefectural Police Headquarters
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Zaitsu Kei
Forensic Science Laboratory, Osaka Prefectural Police Headquarters
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Zaitsu Kei
Forensic Science Laboratory Osaka Prefectural Police Headquarters
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