Forensic Toxicological Determination of Surfactant by Liquid Chromatography/Electrospray Ionization Mass Spectrometry and Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry

概要

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A procedure for identifying surfactants was investigated by liquid chromatography/electrospray ionization mass spectrometry (LC/EST-MS) and liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) from the forensic toxicological point of view. The analysis of anionic, cationic, and nonionic surfactants in both negative and positive mode revealed that anionic and cationic surfactants are detected as M ions in the negative mode and M^4 ions in the positive mode, respectively, while [M+H]^4 ions or [M+NH_4]^4 ions appeared for nonionic surfactants in the positive mode. Anionic surfactants (linear alkylbenzene sulfonate and polyoxyethylene alkyl ether sulfate) were successfully extracted using a weak anion exchange cartridge, with recovery rates of 53.8-76.7%. Cationic surfactant (benzalkonium) was also easily extracted using a weak cation exchange cartridge with a recovery rate of 107%. When aqueous solutions of cationic, anionic, and nonionic surfactants were concentrated to dryness, the recovery rates ranged from 65.8% to 124%. By analyzing anionic surfactants (alpha-olefine sulfate, polyoxyethylene alkyl ether sulfate, and linear alkylbenzene sulfonate) in the product ion scan mode in LC/ESI-MS/MS, it was possible to identify the structure of the hydrophilic group of surfactants, and MS/MS was confirmed to be a powerful technique for classification.
公益社団法人日本薬学会の論文
2003-04-01