Antidepressant-Like Effect of Cordyceps sinensis in the Mouse Tail Suspension Test(Pharmacognosy)
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概要
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Cordyceps sinensis (CS) has been known as a component of traditional medicines that elicit various biological effects such as anti-fatigue, immunomodulatory, and hypoglycemic actions. Since it has been well-established that fatigue is closely related to depression, we used the tail suspension test (TST) in mice to examine the antidepressant-like effects of hot water extract (HWCS) and supercritical fluid extract (SCCS) of CS. Immobility time in the TST was reduced by administration of SCCS (2.5-10 ml/kg,p,o.) dose-dependently though it was not reduced by treatment with HWCS (500-2000 mg/kg,p.o.). Neither HWCS nor SCCS altered locomotor activity in the open field test, excluding the possibility that the effect of SCCS is due to activation of locomotion. Pretreatment with prazosin (an adrenoreceptor antagonist) or sulpiride (a dopamine D2 receptor antagonist) reduced the effect of SCCS on the immobility time. In contrast, pretreatment with p-chlorophenylalanine (p-CPA, a serotonin synthesis inhibitor) did not alter the anti-immobility effect of SCCS. The last finding is consistent with an additional observation that SCCS had no effect on head twitch response induced by 5-hydroxy-L-tryptophan in mice. Taken altogether, these results suggest that SCCS may elicit an antidepressant-like effect by affecting the adrenergic and dopaminergic systems, but not by affecting the serotonergic system.
- 社団法人日本薬学会の論文
- 2007-09-01
著者
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Kawasaki Aya
Noevir-keio Research Laboratory Noevir Co. Ltd.
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Kawasaki Aya
ノエビア慶応リサーチラボラトリー
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MATSUOKA Masaaki
Departments of Hematology and Oncology, Institute of Medical Science, University of Tokyo
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Nishizawa Koji
Noevir-keio Research Laboratory Noevir Co. Ltd.
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TORII Kosuke
Noevir-Keio Research Laboratory, Noevir Co., Ltd.
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KATADA Masanori
Noevir-Keio Research Laboratory, Noevir Co., Ltd.
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ITO Minoru
Noevir-Keio Research Laboratory, Noevir Co., Ltd.
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TERASHITA Kenzo
Department of Cell Biology and Neuroscience, KEIO University School of Medicine
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AISO Sadakazu
Department of Cell Biology and Neuroscience, KEIO University School of Medicine
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Katada Masanori
Noevir-keio Research Laboratory Noevir Co. Ltd.
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Torii Kosuke
Noevir-keio Research Laboratory Noevir Co. Ltd.
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Aiso Sadakazu
Department Of Anatomy Keio University School Of Medicine
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Aiso Sadakazu
Department Of Cell Biology And Neuroscience Keio University School Of Medicine:department Of Anatomy
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Terashita Kenzo
Department Of Cell Biology And Neuroscience Keio University School Of Medicine:department Of Anatomy
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Matsuoka Masaaki
Department Of Cell Biology And Neuroscience Keio University School Of Medicine
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Ito Minoru
Noevir-keio Research Laboratory Noevir Co. Ltd.
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Nishizawa Koji
Noevir-keio Res. Lab. Noevir Co. Ltd.
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