Regioselective Modification of Lysine's Amino Groups by Proteases(Organic Chemistry)

スポンサーリンク

概要

• 論文の詳細を見る

• The regioselectivity of six serine proteases for the amino groups of lysine was investigated. α-Chymotrypsin showed a preference for the α-amino group, although the selectivity can be varied 10-fold depending on the reaction medium. Subtilisin Carlsberg and other bacterial proteases were highly specific for the ε-amino group, regardless of the reaction medium: they were used as catalysts for the preparative synthesis of isopeptides in anhydrous tert-amyl alcohol.

• 社団法人日本農芸化学会の論文
• 1991-12-23

著者

• Itoh Isamu

  Ashigara Research Laboratories Fuji Photo Film Co. Ltd.

• Ono Mitsunori

  Ashigara Research Laboratories Fuji Photo Film Co. Ltd.

• Kitaguchi Hiroshi

  Ashigara Research Laboratories Fuji Photo Film Co. Ltd.

• KLIBANOV Alexander

  Department of Chemistry, Massachusetts Institute of Technology

• Klibanov Alexander

  Department Of Chemistry Massachusetts Institute Of Technology

関連論文

• Conformational Analysis for Tetra Peptides of RXDS (X=Arg, Leu and D-Leu)
• Effect of the Substituent Groups of SCM-Chitin-RGDS Conjugate on Inhibitory Activity of Tumor Metastasis
• Stabilizing Effect of Diphytanylphosphate on Dipalmitoylphosphatidylcholine Bilayer Membrane
• Polypeptide Liposome by Spontaneous Condensation in Bilayer Membranes
• Regioselective Modification of Lysine's Amino Groups by Proteases(Organic Chemistry)

スポンサーリンク