Stimulation of Liver Translational Elongation Induced by Refeeding a Complete Diet to Starved Rats(Biological Chemistry)

概要

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The translational elongation activity in hepatic protein synthesis was compared analytically between starved and refed young rats using an efficient liver slice system. The average ribosome transit time and chain completion time as an estimate of the elongation activity of peptide synthesis were measured. The results were as follows: 1) the average ribosome transit time of liver slices from refed rats was 2.8 min and that from starved rats was 3.6 min; and 2) the average chain completion time of starved rats was estimated at 3.4 min and that of refed rats at 2.7 min. These results indicate- that refeeding a complete diet to a starved rat significantly shortens the ribosome transit time or peptide chain completion time by about 0.7 to 0.8 min. This stimulation of elongation activity contributes in part to the rapid enhancement of liver protein synthesis induced by refeeding in starved rats. The possible mechanism for this induction should be proposed as posttranscriptional control since the amount and size distribution of hepatic polyA(+)mRNA was conserved after refeeding to the starved rats.
社団法人日本農芸化学会の論文
1990-07-23