Molecular Cloning of cDNA Encoding a Human Heat-shock Protein Whose Expression is Induced by Adenovirus Type 12 E1A in HeLa Cells(Biological Chemistry)

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概要

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• We have identified by differential plaque hybridization, human cDNA clones encooding a member of a heat-shock protein family (hsp 90α) in the cDNA library of Adenovirus Type 12 E1A transfected HeLa cells. The complete nucleotide sequence of one of the clones (pHB76-114A) was identified. The sequence of 2912 base pairs had a single reading frame with a coding potential for an 84,672-Da protein. The amino acid sequence was highly homologous, but not identical, to that of the human hsp 90α gene isolated from human peripheral blood lymphocytes [M. Yamazaki, K. Akaogi, T. Miwa, T. Imai, E. Soeda and K. Yokoyama, Nucleic Acids Res., 17, 7108 (1989)]. This cDNA hybridized with RNA species which increased 5- to 20-fold upon heat shock and more than 5-fold in the differentiation stage of human Tera 2 cells.

• 社団法人日本農芸化学会の論文

著者

• Yamazaki Masaaki

  Technical Division Fujiya Co.

• Tashiro Hiroyuki

  Technical Division Fujiya Co.

• Yokoyama Kazushige

  Laboratory For Molecular Regulation Of Aging Frontier Research Program Riken (the Institute Of Physi

• SOEDA Ei-ichi

  Gene Bank, Frontier Research Program, RIKEN (The Institute of Physical and Chemical Research)

• Soeda Ei-ichi

  Gene Bank Frontier Research Program Riken (the Institute Of Physical And Chemical Research)

関連論文

• Molecular Cloning of cDNA Encoding a Human Heat-shock Protein Whose Expression is Induced by Adenovirus Type 12 E1A in HeLa Cells(Biological Chemistry)

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