Stabilization of an Unstable _L-Leucine Producing Strain of Corynebacterium glutamicum by Enhancement of _L-Valine Biosynthesis(Microbiology & Fermentation Industry)

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概要

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• The L-leucine productivity of an L-leucine producer, Corynebacterium glutamicum H-1204, was unstable due to reversion, which was assumed to be caused by the depletion of intracellular L-valine. The genetic enhancement of L-valine biosynthesis was attempted for stabilization using L-valine accumulation as an index. Strain AB-47, derived as an α-aminobutyrate resistant mutant, accumulated L-valine as a by-product besides L-leucine. The L-leucine productivity of strain AB-47 was remarkably stabilized under conditions under which that of parental strain H-1204 became unstable. These results indicate that the balanced biosynthesis of metabolites is important for the breeding of a stable amino acid producer.

• 社団法人日本農芸化学会の論文
• 1988-06-23

著者

• Nakanishi Toshihide

  Tecknical Research Laboratories Hofu Plant Kyowa Hakko Kogyo Co. Ltd.

• Azuma Tomoki

  Tecknical Research Laboratories Hofu Plant Kyowa Hakko Kogyo Co. Ltd.

関連論文

• Stabilization of an Unstable _L-Leucine Producing Strain of Corynebacterium glutamicum by Enhancement of _L-Valine Biosynthesis(Microbiology & Fermentation Industry)
• Enzymatic Background for the Reversion or Stabilization of an _L-Leucine Producing Strain of Corynebacterium glutamicum(Microbiology & Fermentation Industry)

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