Inhibitory Effect of Coffee Extract against Some Mutagens(Food & Nutrition)
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概要
- 論文の詳細を見る
The effects of coffe extracts on mutagenicity were studied using the Salmonella typhimurium system. Coffe extracts showed inhibitory effects on the mutagenicity of such mutagens as 3-amino-1-methyl-5H-pyrido[4, 3-b]indole (Trp-p-2), 2-acetylaminofluorene (AAF), and benzo(a)pyrene (B(a)P), whose mutagenicity require metabolic activation by rat liver microsomal fraction, S-9 mix. The inhibition of mutagenicity increased in proportion to the level of roasting or to the darkness in color of the coffee extracts. When the coffee extracts were applied to a Sephadex G-50 column, two color pigment peaks were observed, the second peak showing the inhibitory activity towards mutagenicity. The inhibitory substance towards the mutagenicity was formed only in a heat-treated mixture of sucrose with either chlorogenic or caffeic acid, among various heat-treated combinations of components in raw coffee beans. The decrease of mutagenicity by coffee extracts was due to inhibiting the metabolic activation by S-9 mix.
- 社団法人日本農芸化学会の論文
- 1986-12-23
著者
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Yamaguchi Tsutomu
Department of Agricultural Chemistry, University of Tokyo
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Yamaguchi T
Kanazawa Univ. Kanazawa Jpn
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IKI Makiyo
Department of Living and Health, Joetsu University of Education
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Iki Makiyo
Department Of Living And Health Joetsu University Of Education
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Yamaguchi Tsutomu
Department Of Agricultural Chemistry University Of Tokyo
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