Cinical implications of histamine neurons activation driven by mastication and L-histidine:an efficient therapeutic apporoach to visceral far reduction and weight loss (2006年度日本味と匂学会第40回大会) -- (Symposium 1: Oral Health Science: Taste, Olfaction, Food and

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概要

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• The present topics aim to demonstrate that mastication and/or L-histidine which activate histamine neurons are effective on weight and visceral fat reduction. Depletion of neuronal histamine from the mesencephalic trigeminal sensory nucleus (Me5), a mastication center, reduced eating speed, but that from the ventromedial hypothalamus (VMH), a satiety center, increased both meal size and its duration leaving eating speed unaffected. Turnover of neuronal histamine in the Me5 elevated at the early phase of feeding and that in the VMH did at the later phase. This elevated turnover was abolished by gastric intubations of an isocaloric liquid diet or an equivolume of water. Mastication-induced activation of histamine neurons suppressed physiological food intake through H_1-receptor in the hypothalamic paraventricular nucleus and the VMH. On the other hand, the histamine neurons activation accelerated lipolysis particularly in the visceral adipose tissues and up-regulated mRNA expression of uncoupling proteins through sympathetic efferent nerve. Mastication thus plays an important role as a potent input signal to activate histamine neurons. In fact, mastication before meal decreased visceral adiposity even in obese patients. Our recent findings show histamine neurons make a negative feedback loop tightly with leptin signaling system. Based on those series of our studies, L-histidine was proved effective as brain foods because its oral load activated hypothalamic histamine neurons efficiently as well. Practice of mastication at each meal together with increased consumption of L-histidine-containing foods was useful for improvement of and prevention from morbid obesity and visceral fat accumulation.

• 日本味と匂学会の論文

著者

• Masaki T.

  Dept. Fund. Energy Science, Kyoto University

• MASAKI T

  Dept.of Int.Med.,Inst.of Cli.Med.,Dept.of Pharmacol.and Dept.of Biomed.Eng.,Inst.of Basic Med.Sci.,U

• Yoshimatsu H

  Dept. Int. Med. I Fac. Med. Oita Univ.

• Sakata T

  Dept. Nutr. Sci. Grad. Sch. Heal. Nutr. Sci., Nakamura Gakuen Univ.

• Yoshimatsu H.

  Dept. Int. Med. I, Fac. Med., Oita Univ.

• Sakata T.

  Dept. Nutr. Sci. Grad. Sch. Heal. Nutr. Sci., Nakamura Gakuen Univ.

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