Deconvolution Analysis of the Regeneration Process of Mitomycin C from Prodrug in a Muscle Perfusion System Based on Statistical Moment Theory(Pharmaceutical,Chemical)
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概要
- 論文の詳細を見る
A new experimental system was developed to elucidate the local characteristics of regeneration of drugs from prodrugs and was applied to propyloxycarbonyl mitomycin C (propyl-MMC), a lipophilic prodrug of mitomycin C (MMC). Rabbit hind leg was perfused with a single-pass technique and outflow concentration-time curves of propyl-MMC and regenerated MMC after pulse injection of propyl-MMC were evaluated by using statistical moment analysis. The outflow concentration-time profile after injection of MMC was also analyzed. Through Laplace transformation of the convolution function for the regeneration process, the first three moment parameters (moments) were led to secondary parameters which express the regeneration and sequestration characteristics of the prodrug such as the regeneration and sequestration ratios of the prodrug, mean regeneration time, and variance of the regeneration time. The pharmacokinetic behavior of propyl-MMC and MMC was thus expressed from the viewpoints of distribution, sequestration, regeneration, and dispersion, as well as extent and rate. It was confirmed that lipophilic derivation produced a. larger tissue distribution and that rapid regeneration of the drug from the prodrug resulted in large local bioavailability of the parent drug.
- 社団法人日本薬学会の論文
- 1987-12-25
著者
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渥美 亮
Drug Metabolism & Analytical Chemistry Research Center Developmental Research Laboratories Daiic
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Atsumi Ryo
Drug Metabolism & Analytical Chemistry Research Center Developmental Research Laboratories Daiic
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橋田 充
Faculty Of Pharmaceutical Sciences Kyoto University
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角谷 敏之
Faculty of Pharmaceutical Sciences, Kyoto University
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渥美 亮
Faculty of Pharmaceutical Sciences, Kyoto University
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住本 悦子
Faculty of Pharmaceutical Sciences, Kyoto University
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住本 悦子
Faculty Of Pharmaceutical Sciences Kyoto University
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角谷 敏之
Faculty Of Pharmaceutical Sciences Kyoto University
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