Effect of Catechol on the Photo-Induced Activation of Bleomycin(Medicinal Chemistry,Chemical)

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概要

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• Bleomycin decreases the melting temperature (T_m) of deoxyribonucleic acid (DNA) determined by the optical density and viscosity methods and breaks the DNA strand in the presence of 1,2-benzenediol (catechol). The effect of bleomycin in the presence of catechol is.markedly in acidic solution. However, in contrast with the case of sulfhydryl compounds such as 2-hydroxy-1-ethanethiol (2-mercaptoethanol), catechol inhibits the interaction of ultraviolet (UV)-irradiated bleomycin with DNA. These results show that catechol has two functions, i.e., increasing the activity of non-irradiated bleomycin and inhibiting that of UV-irradiated bleomycin. Moreover, it was demonstrated that irradiation is not effective for enhancing the antibacterial activity of bleomycin.

• 公益社団法人日本薬学会の論文
• 1987-11-25

著者

• 森 弘正

  Laboratory Of Theoretical And Molecular Biology Faculty Of Pharmaceutical Sciences Kumamoto Universi

関連論文

• Effect of Ultraviolet Irradiation on the Antitumor Activity of Bleomycin
• Effects of Photo-Activated Bleomycin on Deoxyribonuclease I, Exonuclease III and Deoxyribonucleic Acid Polymerase I Reactions
• Effects of Acid and Temperature on the Activity of Bleomycin
• Effect of Catechol on the Photo-Induced Activation of Bleomycin(Medicinal Chemistry,Chemical)
• In Vitro Activation of Bleomycin by Ultraviolet Irradiation

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