In Vitro Activation of Bleomycin by Ultraviolet Irradiation

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概要

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• Irradiation of bleomycin with ultraviolet (UV) light alters its UV absorption and fluorescence spectra and its interaction with deoxyribonucleic acid (DNA) in vitro. UV-Irradiated bleomycin decreases the melting temperature (T_m) of DNA and enhances the strand breakage of DNA more markedly than non-irradiated bleomycin, in the presence of sulfhydryl compounds. Moreover, the irradiation dose causing the greatest increase of these activities is in agreement with that causing the greatest quenching at 350 nm in the transition of the fluorescence emission maximum to 400 nm.

• 公益社団法人日本薬学会の論文
• 1985-09-25

著者

• 森 弘正

  Laboratory Of Theoretical And Molecular Biology Faculty Of Pharmaceutical Sciences Kumamoto Universi

関連論文

• Effect of Ultraviolet Irradiation on the Antitumor Activity of Bleomycin
• Effects of Photo-Activated Bleomycin on Deoxyribonuclease I, Exonuclease III and Deoxyribonucleic Acid Polymerase I Reactions
• Effects of Acid and Temperature on the Activity of Bleomycin
• Effect of Catechol on the Photo-Induced Activation of Bleomycin(Medicinal Chemistry,Chemical)
• In Vitro Activation of Bleomycin by Ultraviolet Irradiation

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