The Effect of Di-(2-ethylhexyl)phthalate, a Chemical Leached from Blood Bags, on Platelet Adenosine Diphosphate Aggregability(Biological,Chemical)

概要

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Recovery of adenosine diphosphate aggregability of stored platelets took place after incubation at 37℃ with Tyrode/bovine serum albumin solution as well as with fresh plasma. However, recovery with plasma from platelet concentrate (PC) stored in ordinary polyvinyl chloride bags was less, and the extent of the decrease depended upon the length of storage. The level of recovery with stored PC plasma, containing leached di-(2-ethylhexyl)phthalate (DEHP), was the same as that of fresh plasma to which DEHP had been added at the same concentration as found in the stored PC plasma. These results indicate that. DEHP leached into the plasma of stored PC suppresses aggregability recovery. This suppression by DEHP is reversible.
社団法人日本薬学会の論文
1987-10-25