Evaluation of Indomethacin Sustained-Release Suppositories Using a Hydroxypropylmethylcellulose Acetate Succinate-Polyethylene Glycol 2000 Solid Matrix(Pharmaceutical)
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概要
- 論文の詳細を見る
Indomethacin (IM) sustained-release suppositories were prepared by using a solid matrix of cellulose acetate phthalate (CAP) or hydroxypropylmethylcellulose acetate succinate (AS・MF) as a poorly soluble carrier and polyethylene glycol 2000 (PEG 2000) as a soluble carrier, and the utility of AS・MF as a poorly soluble carrier was compared with that of CAP. The release rate of IM from the AS・MF matrix suppositories, as well as that from the CAP matrix suppositories, decreased with increase of the content of AS・MF. The sustained release of IM from the AS・MF matrix suppositories was attributed to the formation of a network structure of AS・MF. Rectal administrations of the CAP or AS・MF matrix suppositories in rabbits resulted in good sustained-release characteristics. The bioavailability of the AS・MF matrix suppositories was higher than that of the CAP matrix suppositories.
- 公益社団法人日本薬学会の論文
- 1987-09-25
著者
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横山 徹
Faculty Of Pharmaceutical Sciences Kanazawa University
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Yokoyama Teruyoshi
Kyoto Pharmaceutical University
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Ohnishi Noriaki
Hospital Pharmacy Kobe University School Of Medicine
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Kuroda Koji
Hospital Pharmacy Kobe University School Of Medicine
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KIYOHARA YOSHIFUMI
Hospital Pharmacy, Kobe University School of Medicine
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KITA YOSHIAKI
Hospital Pharmacy, Kobe University School of Medicine
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Kiyohara Yoshifumi
Department Of Hospital Pharmacy School Of Medicine Kobe University:central Research Lab. Wakunaga Ph
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