Effect of the Molecular Weight of Polythylene Glycol on the Bioavailability of Indomethacin Sustained-Release Suppositories Prepared with Solid Dispersions(Pharmaceutical)
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概要
- 論文の詳細を見る
Conventional suppositories were prepared by using polyethylene glycol (PEG) alone, and sustained-release suppositories were prepared by using hydroxypropylmethylcellulose phthalate (HP55)-PEG 1000, 2000 and 4000 matrices. The effect of the molecular weight of PEG on the in vitro release characteristic and bioavailability in rabbits of indomethacin (IM) in those suppositories was investigated. The release rate of IM from the conventional and matrix suppositories decreased slightly with increase of the molecular weight of PEG. The bioavailability of the conventional suppositories was independent of the molecular weight of PEG, but the bioavailability of the matrix suppositories decreased with increase of the molecular weight of PEG.
- 公益社団法人日本薬学会の論文
- 1987-08-25
著者
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横山 徹
Faculty Of Pharmaceutical Sciences Kanazawa University
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Yokoyama Teruyoshi
Kyoto Pharmaceutical University
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Ohnishi Noriaki
Hospital Pharmacy Kobe University School Of Medicine
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Kuroda Koji
Hospital Pharmacy Kobe University School Of Medicine
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KIYOHARA YOSHIFUMI
Hospital Pharmacy, Kobe University School of Medicine
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KITA YOSHIAKI
Hospital Pharmacy, Kobe University School of Medicine
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Kiyohara Yoshifumi
Department Of Hospital Pharmacy School Of Medicine Kobe University:central Research Lab. Wakunaga Ph
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- Effect of the Molecular Weight of Polythylene Glycol on the Bioavailability of Indomethacin Sustained-Release Suppositories Prepared with Solid Dispersions(Pharmaceutical)