Synthesis and Activity of Optical Isomers of Nipradilol(Medeicinal Chemistry,Chemical)
スポンサーリンク
概要
- 論文の詳細を見る
Four optical isomers of nipradilol (NIP) were prepared from (3R)- or (3S)-3,4-dihydro-8-hydroxy-3-nitroxy-2H-1-benzopyran by glycidylation and animation, and evaluated for β-blocking and vasodilating activities. The order of potency of β-blocking activity was S,R-NIP>>S,S-NIP>R,R-NIP>>R,S-NIP. As regards vasodilating activity, S,R-NIP and R,R-NIP were more potent than S,S-NIP and R,S-NIP.
- 公益社団法人日本薬学会の論文
- 1987-09-25
著者
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Shiratsuchi Masami
Tokyo Research Laboratories Kowa Co. Ltd.
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Takenaka Fumio
Kumamoto Women's University
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KAWAMURA KIYOSHI
Tokyo Research Laboratories, Kowa Company, Ltd.
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AKASHI TOSHIHIRO
Tokyo Research Laboratories, Kowa Company, Ltd.
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ISHIHAMA HIROSHI
Tokyo Research Laboratories, Kowa Company, Ltd.
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NAKAMURA MASAKI
Tokyo Research Laboratories, Kowa Company, Ltd.
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Ishihama H
Kowa Co. Ltd. Tokyo Jpn
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Kawamura Kiyoshi
Tokyo Research Laboratories Kowa Company Ltd.
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Akashi T
Kowa Co. Ltd. Tokyo Jpn
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Nakamura Masaki
Tokyo Research Laboratories Kowa Company Ltd.
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Nakamura Masaki
Tokyo Research Laboratories Kowa Co. Ltd.
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TAKENAKA Fumio
Kumamoto University
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