Studies on Diazepines. XXVII. : Syntheses of Fully Unsaturated 1H- and 3H-1,4-Benzodiazepines form 4-Quinolyl Azides(Organic,Chemical)

スポンサーリンク

概要

• 論文の詳細を見る

• Irradiation of the 4-azidoquinolines (7a-d) in a 1:1 mixture of methanol and dioxane containing sodium methoxide resulted in ring expansion to form the unstable fully unsaturated 1H-1,4-benzodiazepines (9a-d), which were tautomerized to the stable 3H-1,4-benzodiazepines (10a-d) by further treatment with sodium methoxide. Acetylation of the 3H-diazepines (10a and 1Od) resulted in tautomerization to afford the 1-acetyl compounds 13a and 13d, which are the first isolated examples of 1H-1,4-benzodiazepines. From these fully unsaturated diazepines (10 and 13), the 2,3-dihydro-1H-1,4-benzodiazepines (14-18) and their 5-oxo derivatives (19 and 20) were prepared.

• 公益社団法人日本薬学会の論文
• 1987-08-25

著者

• Fujii A

  Univ. Tokyo

• Fujii A

  School Of Pharmacy Hokuriku University

• SASHIDA HARUKI

  School of Pharmacy, Hokuriku University

• FUJII AKIRA

  School of Pharmacy, Hokuriku University

• TSUCHIYA TAKASHI

  School of Pharmacy, Hokuriku University

• Sashida Haruki

  School Of Pharmacy Hokuriku University

• Tsuchiya Takashi

  School Of Pharmacy Hokuriku University

関連論文

• Studies on Diazepines. XXVII. : Syntheses of Fully Unsaturated 1H- and 3H-1,4-Benzodiazepines form 4-Quinolyl Azides(Organic,Chemical)
• 9310 「再」定義について(建築論・理論,建築歴史・意匠)
• Studies on Diazepines. XXVI. : Syntheses of 6H-1,4-Diazepines and 1-Acyl-1H-1,4-diazepines from 4-Pyridyl Azides(Organic,Chemical)
• Studies on Diazepines. XXV. : Syntheses of Fully Unsaturated 1,4-Oxazepines and 1H-1,4-Diazepines Using Photochemical Valence Isomerization of Tricycloheptene Systems(Organic,Chemical)

スポンサーリンク