Effect of Binders on the Formation of Pellets. II. Polyvinylpyrrolidone(Pharmaceutical)

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概要

• 論文の詳細を見る

• The effect of polyvinylpyrrolidone (PVP) powder on the formation of pellets of lactose, paracetamol and phenacetin was studied. The high water-solubility and affinity of lactose for water affect pellet growth and properties. Lactose pelletised with PVP powder resulted in some nonwetting of the PVP powder and hence pellet growth was restricted. In the case of phenacetin, a hydrophobic material, pellet growth increased markedly with PVP concentration. This is also attributed to the large viscosity build-up in some regions of the feed material in the pelletiser dish, giving rise to large pellets being formed. Balling of the feed material occurs resulting in an increase in pellet growth. Pelletisation of mixtures of varying proportions of the feed materials showed that the properties of pellets assumed those of the major component.

• 公益社団法人日本薬学会の論文
• 1987-04-25

著者

• Wan Lucy

  Department Of Pharmacy National University Of Singapore

• JEYABALAN THANGARAJAH

  Department of Pharmacy, National University of Singapore

• Jeyabalan Thangarajah

  Department Of Pharmacy National University Of Singapore

関連論文

• A New Method for the Control of Size of Pellets in the Melt Pelletization Process with a High Shear Mixer
• Technique of Measuring Rapid Water Penetration Rate into Tablets(Pharmaceutical)
• Action of Methylcellulose on Disintegration and Dissolution Properties of Tablets
• Operating Conditions for the Formation of Pellets
• Effect of Binders on the Formation of Pellets. II. Polyvinylpyrrolidone(Pharmaceutical)
• Effect of Binders on the Formation of Pellets. I. : Water, Alcohol and Alcohol-Water Mixtures

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