Action of Methylcellulose on Disintegration and Dissolution Properties of Tablets

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概要

• 論文の詳細を見る

• The action of methylcelluloce (MC) of different viscosity on the properties of tablets was studied. The penetration of water into the tablets was retarded by the presence of MC. The disintegration time of tablets was reduced with increasing viscosity of MC and a high level of starch. This correlates with the water penetration data. Dissolution of tablets is governed to a lesser extent by water uptake into the tablets. It is more influenced by the gel formed by MC and the diffusion of drug through this layer. With higher concentration of methylcellulose the adhesiveness of MC becomes more significant in decreasing dissolution of the tablets. MC in contact with water hydrates, swells, gels and becomes adhesive. These actions are affected by starch, MC concentration and viscosity.

• 公益社団法人日本薬学会の論文
• 1986-10-25

著者

• Wan Lucy

  Department Of Pharmacy National University Of Singapore

• Wan Lucy

  Department Of Pharmacy National University Of Singapore Lower Kent Ridge Road Singapore 0511 Singapo

• PRASAD P.P.KANNEGANTI

  Department of Pharmacy, National University of Singapore Lower Kent Ridge Road, Singapore 0511, Sing

• Prasad P.p.kanneganti

  Department Of Pharmacy National University Of Singapore Lower Kent Ridge Road Singapore 0511 Singapo

関連論文

• A New Method for the Control of Size of Pellets in the Melt Pelletization Process with a High Shear Mixer
• Technique of Measuring Rapid Water Penetration Rate into Tablets(Pharmaceutical)
• Action of Methylcellulose on Disintegration and Dissolution Properties of Tablets
• Operating Conditions for the Formation of Pellets
• Effect of Binders on the Formation of Pellets. II. Polyvinylpyrrolidone(Pharmaceutical)
• Effect of Binders on the Formation of Pellets. I. : Water, Alcohol and Alcohol-Water Mixtures

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